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Activated from the antibiotic rifampicin and different plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to precise ligands is species-certain. Activated by Obviously happening steroids, which include pregnenolone and progesterone. Binds to the reaction aspect in the promoters of your CYP3A4 and ABCB1/MDR1 gen